Industry News_Novabio-chem

BLOG

Company News

Industry News

Home

How to choose a suitable peptide synthesis technique?

How to choose the right peptide synthesis technology? Basic concepts of peptide synthesis First, we need to clarify what peptide synthesis is. Simply put, peptides are short-chain molecules made up of amino acids linked by peptide bonds. They play many important roles in living organisms, including acting as signaling molecules. The core of peptide synthesis technology is to combine amino acids in a certain order to form the required peptide. So, why is peptide synthesis technology so important? Imagine if we could efficiently synthesize specific peptides, researchers could conduct research and development faster, and may even find breakthroughs in the treatment of unknown diseases. Isn't this exciting? Types of peptide synthesis technology To choose the right peptide synthesis technology, you must first understand the main synthesis methods available. Currently, common peptide synthesis technologies mainly include solid-phase synthesis, liquid-phase synthesis and biosynthesis. 1. Solid-phase synthesis Solid-phase synthesis is one of the most widely used peptide synthesis technologies. The principle of this technology is to fix amino acids on a solid support, and then gradually add other amino acids to finally synthesize the required peptide. The advantages of solid-phase synthesis are high efficiency, convenience, and ease of automation. However, relatively speaking, it has higher requirements for the sequence of amino acids and chemical reaction conditions. 2. Liquid phase synthesis

2025

Key points analysis of Tirzepatide impurities

I. Tirzepatide Basic Information Tirzepatide is a linear peptide composed of 39 amino acids with the molecular formula C₂₂₅H₃₄₈N₄₈O₆₈ and a molecular weight of 4813.45 Da. II. Impurity Sources and Classification Impurities in tirzepatide mainly come from the following aspects: Production process impurities Synthetic residues: including unreacted amino acids, protecting groups (such as Fmoc, Boc), catalysts (such as EDTA, TCEP), and solvent residues. Degradation products: During synthesis, purification, or storage, reactions such as peptide bond breakage, oxidation (such as methionine oxidation), deamidation (such as asparagine deamidation) may generate impurities. Exogenous contamination: Metal ions (such as sodium, potassium), microbial metabolites from production equipment, containers, or the environment

2025

Detailed introduction to Tirzepatide impurities

Tirzepatide impurities are mainly characterized by their diverse sources, structural complexity, the importance of detection and control, and research value. The following is a detailed introduction: Diversity of Sources Introduction during the production process: Tirzepatide is prepared by solid-phase peptide synthesis (SPPS) or liquid-phase synthesis. Incomplete reactions, side reactions, or incorrect connections may occur during the process, leading to the generation of impurities. For example, the coupling reaction of amino acids may be incomplete, or the removal of protecting groups may be incomplete, resulting in by-products. In addition, raw materials (such as amino acids, protecting groups, coupling reagents) or intermediates used in the synthesis process may remain and become impurities. Residues of solvents, catalysts, or other chemical reagents may also introduce impurities. Storage and Transportation Degradation: Tirzepatide may degrade due to environmental factors (such as temperature, humidity, light, pH changes) during storage or transportation, resulting in impurities. For example, the peptide chain may undergo hydrolysis, oxidation, or isomerization to generate degradation products. Introduction of process steps: Certain steps in the production process (such as purification, filtration, freeze-drying) may introduce impurities. For example, by-products or polymers that are not completely removed during the purification process. Structural Complexity Polypeptide Structural Characteristics: Tirzepatide is a linear peptide composed of 39 amino acids, and its unique amino acid sequence and three-dimensional

2025

Unveiling the Mystery of Tirzepatide Impurities

# Unveiling the Mystery of Tirzepatide Impurities In today's biomedical field, the application of tirzepatide is becoming more and more widespread. However, people's understanding of tirzepatide impurities is still vague. What exactly are these impurities? How do they affect the effect of tirzepatide? Today, let us explore and uncover the mysterious veil of tirzepatide impurities. Basic Concepts of Tirzepatide First, it is very important to understand tirzepatide. Tirzepatide is a new type of biological agent mainly used to treat certain diseases. Its mechanism of action is similar to that of naturally occurring peptides in the body, and it can effectively regulate physiological processes in the body. However, tirzepatide may produce some impurities during production and storage. What exactly are these impurities? What are Tirzepatide Impurities? Simply put, tirzepatide impurities refer to non-target components that are accidentally formed during the tirzepatide production process. These components may be caused by impure raw materials, changes in reaction conditions, or decomposition during storage. Imagine putting an apple in water. If the water is not clean, the apple may become less delicious. Similarly, the quality of tirzepatide will also be affected by these impurities. Types of Impurities Tirzepatide impurities can be mainly divided into

2025

Retatrutide impurity analysis

Retatrutide is a novel triple receptor agonist (GLP-1/GIP/GCGR). Its impurities refer to substances with different structures from the target molecule produced during synthesis, storage, or use, which may affect safety and stability. The main sources of impurities include:

2025

Detailed Analysis of Semaglutide Impurities

The impurity control of Semaglutide needs to run through the entire process of synthesis, purification, and storage. Analysis is achieved through advanced technologies such as MALDI-TOF MS and HPLC, combined with process optimization and strict quality control standards. The strict requirements of regulatory agencies (such as FDA, EMA) further ensure that impurity levels are within a safe range.

2025

Technological innovation is the key to core competitiveness

Our group believes that in the age of economic globalization and information, informatization will be the only way for SMEs to enhance their competitiveness, and E-Business will be the key path for enterprises to achieve informatization. Therefore, our group will continue to focus on promoting the E-Business and informatization process of SMEs in China, constantly innovating and launching more and better services to build intelligent Chinese enterprises and achieve wise entrepreneurs!

2024

Informatization will be the only way for SMEs to enhance their competitiveness

The combination of AI website building technology and search engine optimization (SEO) is leading a new wave in website construction. This article will discuss how these two aspects combine to help websites improve ranking, attract traffic, and increase search engine discoverability. The focus is on how this new collaborative approach helps websites stand out in search results.

2024

< 1 2 >

COOKIES

Our website uses cookies and similar technologies to personalize the advertising shown to you and to help you get the best experience on our website. For more information, see our Privacy & Cookie Policy

COOKIES

required

These cookies are necessary for basic functions such as payment. Standard cookies cannot be turned off and do not store any of your information.

analyze

These cookies collect information, such as how many people are using our site or which pages are popular, to help us improve the customer experience. Turning these cookies off will mean we can't collect information to improve your experience.

Feature

These cookies enable the website to provide enhanced functionality and personalization. They may be set by us or by third-party providers whose services we have added to our pages. If you do not allow these cookies, some or all of these services may not function properly.

advertise

These cookies help us understand what you are interested in so that we can show you relevant advertising on other websites. Turning these cookies off will mean we are unable to show you any personalized advertising.

+86-551-62626599-807

Address: Model B204, B205-1, Hi-tech Capital City High-end Equipment Incubation Base, No. 23, Hangbu Road, Baiyan Science Park, Hi-Tech Zone, Hefei City

Tel:+86-551-62626599-807

Sales Tel: 19856166839; 15705607678; 17354056623

Fax: 0551-62869631

E-mail: sales@bankpeptide.com