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Polymyxin B nonapeptide
Name：
Polymyxin B nonapeptide
Category：
Molecular Weight：
963.15
Molecular Formula：
C43H74N14O11
CAS NO：
86408-36-8
Sequence：
NH2-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr10)
Functions and Effects：
Polymyxin B nonapeptide is a cationic cyclic peptide composed of 9 amino acids, featuring 5 Dab residues in its sequence. Its primary functional group is the amino group, and it is a polypeptide derived from the antibiotic polymyxin B. Polymyxin B nonapeptide interacts with the outer membrane of Gram-negative bacteria, enhancing membrane permeability by promoting hydrophobic diffusion. Notably, Polymyxin B nonapeptide exhibits low toxicity, lacks direct bactericidal activity, yet retains its ability to sensitize Gram-negative bacteria to several antibiotics by permeabilizing their outer membranes.
Molecular Structure Formula：
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